Keyron nomme un nouveau président-directeur général

Carl D Francis prend les rênes du groupe de technologies médicales axé sur le renversement du diabète, de la stéatohépatite non-alcoolique (SHNA) et de l’obésité

LONDRES, 07 févr. 2023 (GLOBE NEWSWIRE) — Keyron, le groupe de technologies médicales axé sur le renversement du diabète de type 2, de la stéatohépatite non-alcoolique (SHNA) et de l’obésité via une plateforme de dispositifs médicaux innovants, a annoncé aujourd’hui la nomination de Carl D Francis au poste de président-directeur général.

« La hausse constante de l’obésité, du diabète et de toutes les formes de stéatose hépatique constitue l’un des plus grands défis auxquels le monde est confronté aujourd’hui. Des milliards de personnes sont littéralement affectées et les chiffres ne cessent d’augmenter rapidement », a déclaré M. Francis. « La technologie de Keyron change entièrement la donne. Un traitement innovant, non-chirurgical, administré de manière endoscopique et entièrement réversible est extrêmement prometteur en tant qu’alternative aux interventions bariatriques drastiques. Je suis très fier et honoré de faire partie de Keyron. »

D’après l’American Diabetes Association, 37 millions d’Américains souffrent aujourd’hui de diabète, et 96 millions sont atteints de prédiabète. Le lien entre l’obésité et le diabète est bien établi, et selon les prévisions de la World Obesity Federation dans son Atlas 2022 récemment publié, 67 % des femmes et 51 % des hommes dans les Amériques vivront avec l’obésité (IMC ≥ 30) d’ici 2030.

La technologie brevetée de Keyron est conçue pour être une procédure ambulatoire entièrement endoscopique fournissant des avantages gastriques identiques ou supérieurs aux interventions chirurgicales de pontage gastrique, notamment un renversement du diabète de type 2 et de l’obésité, ainsi que de la SHNA et de la fibrose hépatique.

Suite à des études fructueuses réalisées sur des rongeurs en 2019 puis sur des porcs en 2022, les premiers essais de Keyron sur des humains devraient débuter au début de l’année 2024. Keyron espère obtenir l’approbation de la FDA d’ici 2028, et un lancement est prévu aux États-Unis en tant que premier marché cible. La société projette désormais de lever un tour de financement de série A de 15 millions de dollars.

Le Dr Giorgio Castagneto Gissey, président du conseil d’administration de Keyron, a commenté : « Nous sommes ravis que Carl prenne la direction de Keyron alors que nous entrons dans cette phase cruciale de notre développement. Carl apporte son énergie, sa concentration et son expérience de leadership pour s’assurer que nous réalisons notre plein potentiel. Keyron a toujours eu des membres du conseil d’administration et des conseillers médicaux de haut niveau et de renommée mondiale, et nous continuons à recruter des personnes remarquables. Nous sommes extrêmement ravis d’avoir été en mesure d’attirer Carl. »

M. Francis a précédemment occupé le poste de PDG du célèbre groupe de nanotechnologies P2i. Au cours de son mandat, le groupe est passé d’une poignée d’employés à un leadership mondial dans le domaine du nano-revêtement fonctionnel. Plus récemment, il était le PDG du groupe de technologies médicales basé au Royaume-Uni Eyoto, qui se spécialise dans les technologies avancées dans les secteurs optiques et ophtalmiques. Il a débuté sa carrière en tant qu’expert-comptable certifié aux États-Unis, est membre de Mensa et titulaire d’un BSc de l’université de Cincinnati.

CONTACT

Pour tout complément d’information, veuillez contacter :

  • Aux États-Unis – Carl D Francis à l’adresse c.francis@keyron.com ou en composant le +1 (912) 429-3800
  • En Europe – Dr Giorgio Castagneto Gissey à l’adresse gcgissey@keyron.com ou en composant le +44 7975 911101

À PROPOS DE KEYRON

Basée au Royaume-Uni, Keyron est une société qui se spécialise dans les plateformes technologiques et les dispositifs médicaux au stade préclinique visant un traitement hautement efficace pour les maladies métaboliques. La solution brevetée ForePass™ de Keyron est un dispositif médical innovant conçu pour inverser de manière sûre le diabète de type 2, ainsi que la stéatohépatite non-alcoolique (SHNA) et l’obésité. La société a déjà démontré un renversement complet de la résistance à l’insuline dans des études réalisées sur des animaux, dont elle a récemment publié les résultats dans la revue The Lancet EBioMedicine. Keyron prévoit d’effectuer prochainement des essais cliniques en Amérique du Sud et vise à mener par la suite d’autres études cliniques aux États-Unis. Ses fondateurs, directeurs, conseillers et investisseurs incluent certains des professeurs et leaders d’opinion les plus réputés et cités à l’échelle mondiale dans le domaine des maladies métaboliques. La société est soutenue par plusieurs investisseurs institutionnels basés aux États-Unis et dans la région EMOA.

GlobeNewswire Distribution ID 8744743

One Activist’s Climate Fast Stirs Demands for Change in Ladakh

Enthusiasm has turned to frustration and bitterness for a leading conservation activist in India's Himalayan region of Ladakh, which was separated from Jammu and Kashmir when the former state's limited autonomy was controversially revoked in 2019.

The move by India's parliament prompted widespread anger and a monthslong security clampdown in the Kashmir Valley, where the Muslim-majority population bristled at the increased control over their lives by the Hindu-led federal government.

But in the Himalayan highlands of Ladakh, the partition of the former state into two union territories with limited local control was seen by the 97% tribal population as an opportunity to set their own path and preserve the region's pristine natural wonders.

More than three years later, that vision has turned to ashes for one of its strongest proponents, Sonam Wangchuk, who recently staged a five-day fast demanding that New Delhi follow through on promises made in 2019.

"We were better off with Jammu and Kashmir than today's [union territory]," Wangchuk lamented in a video he made public before completing his fast at the Himalayan Institute of Alternative Ladakh, which he founded.

A former engineer turned educational reformer, Wangchuk has been working on the development of Ladakh for the last 30 years. He is credited with designing solar-heated buildings and artificial glaciers, while more recently providing the people with better education facilities.

Wangchuk was the 2018 winner of the Ramon Magsaysay Award, sometimes referred to as the Asian Nobel, for "harnessing nature, culture and education for community progress." His life story was the inspiration for one of the lead roles in the 2009 film "3 Idiots," one of the most successful in the history of Indian cinema.

In a telephone interview with VOA, Wangchuk acknowledged his initial support for the partition of Jammu and Kashmir and the revocation of Article 370 in the Indian Constitution, which had granted the region a separate constitution, a state flag, and a high degree of autonomy over its internal affairs.

"On the one hand, it was good for the people of Ladakh to have their own path of development," said the tireless advocate of a carbon-neutral lifestyle, who had hoped the change would help to safeguard the region's fragile ecology. "But on the other hand, we were concerned about how will the safeguards of Article 370 continue?"

Reflecting a growing local consensus, Wangchuk now argues that Ladakh should become a state with its own legislature. And as a key demand of his fast, he appealed to Prime Minister Narendra Modi to grant the region special protections under the Sixth Schedule of the constitution.

Such measures, granting wide powers to local councils, were established to protect primarily tribal populations against exploitation and now exist in special administrative regions in four states in India's remote northeast — Assam, Meghalaya, Tripura and Mizoram.

Wangchuk said the ruling Bharatiya Janata Party government had promised to include Ladakh under the Sixth Schedule at the time it was separated from Jammu and Kashmir but that the issue has since been ignored.

The activist's fast, which he began on a frigid hillside before he was placed under house arrest and forced to move to his institute, struck a nerve in the region and mobilized large numbers of like-minded supporters.

"There is no state assembly. The bureaucrats are taking all the decisions. People feel that they have lost their voice, which has created a sense of alienation," political activist Sajjad Kargili told VOA. "Ladakhis are now unitedly raising their voice for statehood and Sixth Schedule."

Tsering Namgyal, the leader of the opposition on the Ladakh Autonomous Hill Development Council, agreed that Wangchuk's climate fast has galvanized public opinion in the region.

"It proved to be a massive boost in getting the demand for the Sixth Schedule echoed nationally and internationally. It remains to be seen what step the government of India and the Home Ministry will take in the wake of such a huge public outcry."

As for his own future plans, Wangchuk said, "I am happy with the response I received nationally and internationally. I want the government to pay attention to people’s concerns and work for their betterment." But if the government still does not pay attention, he said, he will continue to protest until the people's needs are fulfilled.

When asked whether he wanted the region's leaders to join the protest, Wangchuk said that he wouldn't compel anyone, and if they wanted to shake hands in protest, he won't stop them either.

Source: Voice of America

Could a Sprinkle of Moon Dust Keep Earth Cool?

Whether out-of-the-box thinking or a sign of desperation, scientists on Wednesday proposed the regular transport of moon dust to a point between Earth and Sun to temper the ravages of global warming.

Ideas for filtering solar radiation to keep Earth from overheating have been kicking around for decades, ranging from giant space-based screens to churning out reflective white clouds.

But the persistent failure to draw down planet-warming greenhouse gas emissions has pushed once-fanciful geoengineering schemes toward center stage in climate policy, investment and research.

Blocking 1%-2% of the Sun's rays is all it would take to lower Earth's surface by a degree or two Celsius, roughly the amount it has warmed over the last century.

The solar radiation technique with the most traction so far is the 24/7 injection of billions of shiny sulfur particles into the upper atmosphere.

So-called stratospheric aerosol injection would be cheap, and scientists know it works because major volcanic eruptions basically do the same thing. When Mount Pinatubo in the Philippines blew its top in 1991, it lowered temperatures in the northern hemisphere by about 0.5 Celsius for nearly a year.

But there are serious potential side-effects, including the disruption of rain patterns upon which millions depend for growing food.

However, a new study in the peer-reviewed journal PLOS Climate explores the possibility of using moon dust as a solar shield.

A team of astronomers applied methods used to track planet formation around distant stars — a messy process that kicks up vast quantities of space dust — to Earth's moon.

Computer simulations showed that putting lunar dust at a gravitational sweet spot between Earth and Sun "blocked out a lot of sunlight with a little amount of mass," said lead author Ben Bromley, a professor of physics at the University of Utah.

'Balancing marbles'

The scientists tested several scenarios involving different particle properties and quantities in different orbits, looking for the one that would throw the most shade.

Moon dust worked best. The quantities needed, they said, would require the equivalent of a major mining operation on Earth.

The authors stressed that their study was designed to calculate potential impact, not logistical feasibility.

"We aren't experts in climate change or rocket science," said co-author Benjamin Bromley, a professor at the Harvard-Smithsonian Center for Astrophysics.

"We were just exploring different kinds of dust on a variety of orbits to see how effective this approach might be," he added. "We don't want to miss a game changer for such a critical problem."

Experts not involved in the study praised its methodology but doubted whether it would actually work.

"Placing moon dust at the gravity midpoint between Earth and Sun, can indeed reflect heat," said University of Edinburgh professor Stuart Haszeldine.

"But this is like trying to balance marbles on a football — within a week most dust has spun out of stable orbit."

For Joanna Haigh, an emeritus professor of atmospherics at Imperial College London, the study is a distraction.

The main problem, she said, "is the suggestion that the implementation of such schemes will solve the climate crisis whereas it just gives polluters an excuse not to act."

Source: Voice of America